Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218893 | Tetrahedron | 2013 | 6 Pages |
Abstract
N-Heterocyclic carbenes have been employed as highly efficient organocatalysts to mediate silyl-Reformatsky type reaction. In the presence of only 0.5 mol % nucleophilic carbene 1, various aldehydes coupled with α-trimethylsilylethylacetate very smoothly in DMF at room temperature to provide the corresponding β-hydroxyesters in moderate to high yields. α-Trimethylsilylketone and α-trimethylsilylamide can also undergo the addition reaction to give β-hydroxyketone and β-hydroxyamide in moderate yields.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiao-Lei Zou, Guang-Fen Du, Wan-Fu Sun, Lin He, Xiao-Wei Ma, Cheng-Zhi Gu, Bin Dai,