| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218912 | Tetrahedron | 2013 | 9 Pages |
Abstract
Fluorination of bioactive compounds is an important step in drug discovery and development. Fluorination has been extensively studied in acyclic systems, carbocycles, and fused heterocycles. However, there is no report on fluorination of azepanes. As azepanes are components of many biologically active substances and natural products. We herein present the first fluorination examples of substituted azepanes. Fluoroazepanes were prepared by deoxyfluorination diastereospecifically in excellent yields. The absolute configuration at the fluorination site was unambiguously assigned by 2D NMR spectroscopy.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alpesh Ramanlal Patel, Fei Liu,