Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218923 | Tetrahedron | 2013 | 7 Pages |
Abstract
Starting from Morita-Baylis-Hillman (MBH) adducts, an approach for the synthesis of oxopyrazolidines, arylidene-oxopyrazolidines, and oxo-2,5-dihydropyrazoles is described. The method is based on a tandem process involving a Michael addition of amino-guanidine into silylated and acetylated MBH adducts, followed by intramolecular cyclization. The use of acetylated MBH adducts led also to the synthesis of unusual pyrazoles, which is facilitated by an unexpected base-mediated equilibrium.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
José Tiago M. Correia, Manoel T. Jr., Hugo Santos, Cláudio F. Tormena, Fernando Coelho,