| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5218949 | Tetrahedron | 2012 | 9 Pages |
Abstract
Empirical information on the acidity of the propargylic proton from our previous work allowed us to develop novel synthetic transformations of readily available terminally trifluoromethylated propargylic alcohols 1 into the corresponding allenyl tosylates 3a, 1-tosyloxy- or 1-acyloxy-4,4,4-trifluorobutan-2-ones 4, and 2-(2,2,2-trifluoroethyl)prop-2-en-1-ones 5, which was enabled by such common bases as NaOH and tertiary amines for affecting ready abstraction of this proton.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takashi Yamazaki, Yohsuke Watanabe, Nao Yoshida, Tomoko Kawasaki-Takasuka,