Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218975 | Tetrahedron | 2013 | 8 Pages |
Abstract
Plakortides R-U, four new polyketide endoperoxides, have been isolated from the marine sponge Plakinastrella mamillaris. Their structures were elucidated on the basis of extensive NMR spectroscopic (1H and 13C, COSY, HSQC, HMBC, and ROESY) and MS analyses and by chemical methods. In addition, a new method for the unambiguous stereochemical elucidation of 3,6-disubstituted 1,2-dioxines, frequently isolated from Plakinidae sponges, is reported. Pharmacological analysis demonstrated that plakortide U is endowed with in vitro antiplasmodial activity against a chloroquine-resistant strain.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carmen Festa, Simona De Marino, Maria Valeria D'Auria, Orazio Taglialatela-Scafati, Eric Deharo, Sylvain Petek, Angela Zampella,