Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5218999 | Tetrahedron | 2012 | 5 Pages |
Abstract
2-C-Methyl-d-erythritol-4-phosphate (MEP) is a key chemical intermediate of the non-mevalonate pathway for isoprenoid biosynthesis employed by many pathogenic microbes. MEP is also the precursor for the synthesis of 4-diphosphocytidyl-2-C-methyl d-erythritol (CDP-ME), another key intermediate of the non-mevalonate pathway. As this pathway is non-existent in higher animals, including humans, it represents great opportunities for novel antimicrobial development. To facilitate the in-depth studies of this pathway, we reported here a formal synthesis of CDP-ME through a new synthesis of 2-C-methyl-d-erythritol-4-phosphoric acid from d-(+)-arabitol.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sina I. Odejinmi, Rafael G. Rascon, Wyman Chen, Kent Lai,