Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219070 | Tetrahedron | 2012 | 5 Pages |
Abstract
The new type of non-catalytic cascade reaction was found: the direct multicomponent reaction of acenaphthenequinone, cyclic CH-acids, and malononitrile to form spiroacenaphthylene heterocycles. The direct heating in water acenaphthenequinone, cyclic CH-acids, and malononitrile at 80 °C results in the formation of spiroacenaphthylene heterocycles in 90-95% yields. Thus, a new simple and efficient green 'one-pot' method to synthesize substituted spiroacenaphthylene frameworks was found directly from simple starting compounds. The application of this convenient green multicomponent method is also beneficial from the viewpoint of diversity-oriented large-scale processes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michail N. Elinson, Alexey I. Ilovaisky, Valentina M. Merkulova, Pavel A. Belyakov, Fructuoso Barba, Belen Batanero,