Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219076 | Tetrahedron | 2012 | 8 Pages |
Abstract
Starting from commercial secondary amines, a one-pot procedure allows a direct access to enaminones through a one-pot deprotonation/oxidation/in situ re-deprotonation/acylation sequence without intermediate isolation of the intermediate Schiff base or its corresponding enamine tautomer. An alternative one-pot sequence involving a similar oxidation step followed by one or two alkylation steps yields, after acidic work-up, functionalized ketones directly from the parent amine. This process has been applied to an expeditious synthesis of the male aggregation pheromone of the cereal leaf beetle Oulema melanopus.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alice Chevalley, Jean-Pierre Férézou,