Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219098 | Tetrahedron | 2012 | 7 Pages |
Abstract
Direct fluorination at the 2â²-arabino-position of a pyrimidine nucleoside has been a long-standing challenge, yet we recently reported such a stereospecific fluorination for the first time in the synthesis of [18F]FMAU, albeit in low yields. Herein we report the results of an investigation on stereospecific fluorination on a variety of precursors for synthesis of [18F]FMAU. Several precursors were synthesized in multiple steps and fluorination was performed at the 2â²-arabino-position using K[18F]/kryptofix 2.2.2. All precursors produced [18F]FMAU in low yields.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nashaat Turkman, Vincenzo Paolillo, Juri G. Gelovani, Mian M. Alauddin,