| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219118 | Tetrahedron | 2012 | 7 Pages |
Abstract
Among the various versions of the aldol reaction, the enantioselective reaction between cyclic ketones and aldehydes constitutes a typical reaction model for the evaluation of novel organocatalysts. A multifunctional organocatalyst consisting of a prolinamide moiety, a gem diamine unit and a urea group was successfully employed in this asymmetric transformation. The products of the reaction between various ketones and aldehydes were obtained in high yields (up to 98%) with excellent diastereo- (up to >98:2 dr) and enantioselectivities (up to 99% ee).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Panagiota Revelou, Christoforos G. Kokotos, Panagiota Moutevelis-Minakakis,