| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219130 | Tetrahedron | 2012 | 7 Pages |
Abstract
A set of highly substituted pyrazoles bearing different functional groups on the pyrazole core was developed. Employing a suitable protecting group strategy we could regioselectively introduce various substituents in position 1, 3 and 4 of the pyrazole. This enabled the synthesis of various derivatives of a pyrazole–biscarboxamide with insecticidal activity. During the optimization process we focused on the precise exchange of carboxamide as well as other functional groups based on the concept of bioisosterism.
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