| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219153 | Tetrahedron | 2013 | 9 Pages |
Abstract
An efficient protocol has been developed for the direct ortho-hydroxylation of 2-arylbenzothiazole using Pd(OAc)2 as the catalyst and either of DIB/AcOH or Oxone®/TFA combinations under air atmosphere. Under both these conditions, the methodology tolerates a diverse array of substituents giving good to excellent yields of corresponding ortho-hydroxylated products. Regioselective hydroxylation is observed at the less sterically hindered site of the phenyl ring possessing substituents at its meta position.
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Physical Sciences and Engineering
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