Parikh-Doering oxidation-dehydration-Ugi cyclization cascade in the development of lactams from formidoalkanols (3>chain length>7)

De novo incorporation of N-formylated aminols as strategic substrates in legendary Ugi cyclization. Lactamization of N-formido alkanols is accomplished by a novel Parikh-Doering oxidation-dehydration-Ugi cyclization cascade leading to the formation of lactams up to eight carbons (ring size; n=1-4) in moderate yields using formidoaminol, substituted aniline, and aliphatic/aromatic carboxylic acid derivatives as starting materials.

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