Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219227 | Tetrahedron | 2012 | 5 Pages |
Abstract
A new protocol for the synthesis of polysubstituted isocoumarins from 2-iodobenzoic acid and β-diketone compounds has been developed. The occurrence of C-arylation cyclization reaction in transition-metal-free systems and ortho-induced substrates has been exploited. Reactions using these inexpensive conditions have displayed high functional group tolerance and excellent yields.
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