Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219243 | Tetrahedron | 2012 | 11 Pages |
Abstract
The organocatalysed asymmetric hydrosilylation of a number of N-aryl and alkyl β-substituted enamino esters proceeds in generally good yield and enantioselectivity. Crucial to obtaining high yield and selectivity was the addition of benzoic acid as an additive and under these conditions, both N-alkyl and N-aryl substituents were well tolerated. β-Aryl and alkyl substituents were evaluated and a model proposed to account for the experimental observations based upon enamine tautomerisation and conformational preferences of the reactive ketimine intermediate.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Simon Jones, Xianfu Li,