Synthesis of highly N-substituted indole library via conjugate additions of indoline and their synthetic tool potentials

A comprehensive library of N- or 1-substituted indoles was formed by conjugate additions of indoline with Michael acceptors followed by an oxidation step. Using N-substituted indoles as key Michael donors, the synthesis of 1,3-disubstituted indoles was also accomplished.

Graphical abstractDownload full-size image