Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219274 | Tetrahedron | 2012 | 7 Pages |
Abstract
Acyclic acetals and ketals undergo transacetalisation in the presence of catalytic quantities of indium(III) triflate (In(OTf)3) and diols or triols under solvent-free conditions to generate the corresponding cyclic acetals and ketals in excellent yield. The methodology has been further developed to encompass a tandem acetalisation-acetal exchange protocol, which provides a facile and high yielding route to cyclic ketals from unreactive ketones under very mild reaction conditions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Brendan M. Smith, Tomasz M. Kubczyk, Andrew E. Graham,