| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 52193 | Catalysis Communications | 2011 | 7 Pages |
Sulfonic acid-functionalized ordered nanoporous Na+-montmorillonite (SANM) was used as an efficient catalyst for N-tert-butoxycarbonylation of amines with di-tert-butyl dicarbonate under solvent-free conditions at room temperature. Various aliphatic, aromatic, heterocyclic amines and aminols were protected as their corresponding mono-carbamates in excellent yields and short reaction times. No competitive side reactions such as isocyanate, urea, and N,N-di-Boc formation were observed. The reported method is mild, chemoselective and has the advantages such as heterogeneous catalysis, low cost and the recyclability of the catalyst.
Graphical abstractSulfonic acid-functionalized ordered nanoporous Na+-montmorillonite (SANM) was found to be a mild, novel, efficient and reusable catalyst for N-tert-butoxycarbonylation of amines with di-tert-butyl dicarbonate under solvent-free conditions at room temperature.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► Synthesis of sulfonic acid-functionalized ordered nanoporous Na+-montmorillonite. ► Characterization and application of SANM for N-tert-butoxycarbonylation of amines. ► Catalysis under solvent-free conditions at room temperature. ► Heterogeneous catalysis and recyclability of the catalyst.
