Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219327 | Tetrahedron | 2011 | 6 Pages |
Abstract
A practical route to 6-bromo-5,7-dihydroxyphthalide 5-methyl ether, a versatile intermediate in the synthesis of hericenones and related bioactive polyphenols, was developed. The synthesis features a combination of tandem Michael addition-Claisen condensation and CuBr2-mediated multi-step reactions. With this product in hand, total syntheses of hericenone J and 5â²-deoxohericenone C (hericene A) were achieved.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shoji Kobayashi, Ami Ando, Hiroyuki Kuroda, Shota Ejima, Araki Masuyama, Ilhyong Ryu,