| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219342 | Tetrahedron | 2011 | 5 Pages |
Abstract
An efficient enantioselective synthesis of florfenicol is accomplished in 44.7% overall yield from commercially available p-(methylsulfonyl)benzaldehyde. Key features of this synthesis are the asymmetric aziridination reaction mediated by the Wulff’s catalyst in situ derived from (R)-VANOL and diastereoselectively ring-opening of (2S,3S)-fluoroaziridine 13.
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