| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219454 | Tetrahedron | 2012 | 7 Pages |
Abstract
The first enantioselective total synthesis of rumphellaone A, a cytotoxic 4,5-seco-caryophyllane isolated from the gorgonian coral Rumphella antipathies, has been achieved from a known olefinic alcohol by a 16-step sequence involving Stork's epoxy nitrile cyclization as the key step to concomitantly install a cyclobutane ring and three contiguous stereogenic centers contained in the molecule.
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