Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219462 | Tetrahedron | 2012 | 8 Pages |
Abstract
A chemoselective indole-templated ring-closing metathesis is used to assemble the cyclohepta[b]indole substructure of the indole alkaloid ervitsine. A subsequent intramolecular Heck coupling of the resulting alkene functionality with an amino-tethered vinyl halide accomplishes the closure of the unique 2-azabicyclo[4.3.1]decane framework of the alkaloid with concomitant incorporation of the exocyclic E-ethylidene substituent.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M.-Lluïsa Bennasar, Ester Zulaica, Daniel Solé, Sandra Alonso,