| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219477 | Tetrahedron | 2012 | 9 Pages |
Abstract
Herein we report a study on the enantioselective organocatalyzed cross-aldol reaction of 1-benzothiophene and thiophenecarbaldehydes with different ketones. The reactions were conducted at 0 °C or room temperature to afford the corresponding adducts in high yields and good to excellent ee using different organocatalysts. Interestingly, using (S)-pyrrolidine tetrazole and acetoxyacetone an inversion of the aldol regiochemistry was observed.
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