Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219480 | Tetrahedron | 2012 | 8 Pages |
Abstract
(2,6-Dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl) methoxymethyl chloride [1, monomethoxydiph-enylmethoxylmethyl chloroide (MDPM-Cl)] shows a significant relative stability and 1 reacts with uridine ureido nitrogen in the presence of DBU to form the corresponding protected uridine 8 in 95% yield. The MDPM-protected uridines are stable to a wide variety of conditions utilized for the synthesis of analogs of capuramycin and muraymycins. Significantly, the MDPM protecting group can conveniently be deprotected by using 30% TFA in CH2Cl2. In addition, polymer-bound MDPM-Cl 23 is useful for immobilization of uridine derivatives.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yong Wang, Michio Kurosu,