| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219515 | Tetrahedron | 2012 | 9 Pages |
Abstract
The reaction of N-Boc-protected propargylamine with salicylaldehyde derivatives and their subsequent Nicholas cyclisation reaction to provide a range of novel benzopyrans is reported. The cyclisation reactions proceeded with excellent levels of diastereoselectivity to afford compounds with cis-relative stereochemistry. As far as we are able to ascertain these are the first reported examples of Nicholas cyclisation reactions of propargyl alcohols that bear a terminal alkynyl N-protected amino motif.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peter Brawn, Elizabeth Tyrrell, Mark Carew, Kibur Hunie Tesfa, Iain Greenwood,