Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219549 | Tetrahedron | 2012 | 6 Pages |
Abstract
Phosphine-copper(I) complexes efficiently catalyzed the mono-boration of electron-deficient alkynes in the presence of MeOH and also catalyzed conjugate reductions of alkenylboronates bearing an electron-withdrawing group. The mono-addition of bis(pinacolato)diboron to alkynes catalyzed by a copper-Xantphos complex produced vinylboronates with high regio and stereoselectivity and asymmetric reduction of the vinylboronates by a chiral copper-bisphosphine catalyst allowed the synthesis of valuable chiral boranes with high enantioselectivity. One-pot boration/asymmetric reduction of α,β-unsaturated alkynoates could be conducted with a single copper-phosphine catalyst.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ho-Young Jung, Xinhui Feng, Hyohyun Kim, Jaesook Yun,