| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219556 | Tetrahedron | 2012 | 5 Pages |
Abstract
We report here the use of the DiPPAM-L1 ligand for copper-catalysed asymmetric conjugate addition (ACA) of diethylzinc to various (E)-alkenyl aryl ketones where the aryl ring is either a phenyl group substituted by nitro, chloro or methoxy groups or not substituted, or a naphthyl group. When the conjugate addition was performed in the greener AcOEt solvent with 1 or 2 mol % of Cu(OTf)2/DiPPAM complex, moderate to good yields (45-83%) and high enantioselectivities (up to 98%) were reached.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Magaly Magrez, Joanna Wencel-Delord, Christophe Crévisy, Marc Mauduit,