Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219578 | Tetrahedron | 2012 | 6 Pages |
Abstract
The introduction of organoselenium moieties within the structure of carbohydrates has received attention recently. Herein, we report on the synthesis of selenium-containing neoglycoconjugates and pseudodisaccharides by the reaction of nucleophilic selenium species, generated from sugar diselenides, with chiral N-Boc aziridines and sugar tosylates. The reaction proceeds with moderate to good yields for various substrates. The introduction of organoselenium moieties within the framework of various sugars, with increased levels of complexity, thus allowing the synthesis of disaccharide and glycoconjugate mimetics.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ricardo F. Affeldt, Hugo C. Braga, Lucas L. Baldassari, Diogo S. Lüdtke,