| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219643 | Tetrahedron | 2011 | 6 Pages |
Abstract
Some new mono-, bis-spiro- and dispiro-β-lactams have been synthesized from imines derived from 9H-fluoren-9-one and a ketene derived from 9H-xanthene-9-carboxylic acid or phenoxyacetic acid by a [2+2] cycloaddition reaction in good to excellent yields varying from 45 to 83%. The biological activity of these monocyclic β-lactams was successfully investigated against Plasmodium falciparum K14 resistant strain with excellent EC50 values up to 5 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aliasghar Jarrahpour, Edris Ebrahimi, Erik De Clercq, Véronique Sinou, Christine Latour, Lamia Djouhri Bouktab, Jean Michel Brunel,