Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219654 | Tetrahedron | 2011 | 5 Pages |
Abstract
Reaction of 2-chloroindole-3-carbaldehyde with epibromohydrin gives the expected 1-(oxiran-2-ylmethyl) derivative. However the analogous reaction with epichlorohydrin leads to the formation of the oxazolo[3,2-a]indole skeleton. Some chemical properties of this tricyclic system were investigated. Its reaction with secondary amines unexpectedly proceeds with the opening of the oxazole ring.
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