Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219668 | Tetrahedron | 2012 | 8 Pages |
Abstract
An efficient approach to a wide range of isoindolinones, including 3-monosubstituted and 3,3-disubstituted isoindolinones, from the annulation of N-benzoylsulfonamides with olefins and diazoacetate has been developed. The transformation is broadly compatible with both terminal and internal olefins. Moreover, diazoacetate is for the first time incorporated into an amide-directed C-H functionalization reaction. Specifically, the rhodium complex [{RhCl2Cp*}2] enables the in situ dimerization of diazoacetate in addition to its role in catalyzing C-H functionalization/cross-coupling.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chen Zhu, John R. Falck,