Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219671 | Tetrahedron | 2012 | 7 Pages |
Abstract
The design and synthesis of derivatives of 4-hydroxy-Tamoxifen as potential antagonists of the nuclear receptor LRH-1 are described. Stereoselective McMurry coupling was used to generate the desired internal alkene and a novel method for the synthesis of tetrasubstituted cyclopropane analogues was also developed.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jullien Rey, Haipeng Hu, James P. Snyder, Anthony G.M. Barrett,