Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219679 | Tetrahedron | 2012 | 5 Pages |
Abstract
Wickerols A and B were produced by a fungus, Trichoderma atroviride FKI-3849. Wickerol A showed potent anti-influenza virus activity against strain A/PR/8/34 (H1N1), whereas wickerol B exhibited weaker impact. The anti-influenza virus spectrum between wickerols A and B was different. The cyclization mechanism of the wickerol carbon-skeleton was investigated by incorporation of 13C-labeled acetate. A pathway through the verticillyl cation was predicted.
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