| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219694 | Tetrahedron | 2012 | 5 Pages |
Abstract
AUAP (acidic protease from Aspergillus usamii) could catalyze the direct aldol reactions between aromatic aldehydes and cyclic ketones in acetonitrile (MeCN) in the presence of water. The enantioselectivities of up to 88% ee and diastereoselectivities of up to 97:3 (anti/syn) were achieved. This new activity of protease expands the application of the biocatalyst and provides a novel example of enzymatic promiscuity.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bang-Hua Xie, Wei Li, Yan Liu, Hai-Hong Li, Zhi Guan, Yan-Hong He,