| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219697 | Tetrahedron | 2012 | 8 Pages |
Abstract
We have developed a pragmatic route to the stereogenic skipped 1,3,5-polyols. The strategic transformation includes an organocatalytic enantioselective asymmetric epoxidation, which is either syn- or anti-selective as genesis of chirality and successive SN2 opening reaction by an appropriate functionalized nucleophile, followed by hydroboration/oxidation to generate stereoisomers in good yield. The critical intermediate generated en route to this process is employed in the total synthesis of polyrhacitide A.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gullapalli Kumaraswamy, Akula Narayana Murthy, Kadivendi Sadaiah,