Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219740 | Tetrahedron | 2012 | 7 Pages |
Abstract
A novel one-pot three-component reaction of 6-amino-uracil, isatin, and acetophenone was accomplished through a programmed pH variation for the synthesis of 5-(2-oxoindolin-3-yl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives. The reaction was conducted in a sequential tandem manner to give the oxindole substituted pyrrolo[2,3-d]pyrimidine products in good to excellent yields. Despite of timing all the processes were carried out in one pot. Most of these novel compounds show narrow to good spectrum of antimicrobial activities in vitro.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kurosh Rad-Moghadam, Seyyedeh Cobra Azimi,