Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219743 | Tetrahedron | 2012 | 7 Pages |
Abstract
New diterpene alkaloids, agelasines O-U (1-7), have been isolated from an Okinawan marine sponge Agelas sp. The gloss structures and relative stereochemistries of 1-7 were elucidated from the spectroscopic data. Agelasines O-R (1-4) were the third examples of diterpene alkaloid with a 9-N-methyladenine and a pyrrole units. Agelasine O (1) has a halimane skeleton, while agelasines P-R (2-4) have a clerodane skeleton. Agelasines S-U (5-7) were new diterpene alkaloids with a 9-N-methyladenine unit consisting of a halimane skeleton, a labdane skeleton, and a clerodane skeleton, respectively. Agelasines O-R (1-4) and T (6) showed antimicrobial activities against several bacteria and fungi.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takaaki Kubota, Takahiro Iwai, Azusa Takahashi-Nakaguchi, Jane Fromont, Tohru Gonoi, Jun'ichi Kobayashi,