| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219765 | Tetrahedron | 2012 | 5 Pages |
Abstract
A simple five-step synthetic route toward dizocilpine (1) starting with dibenzosuberenone (2) in 28% of total yield is described. The facile route was carried from by aziridination of dibenzosuberenone (2) with NBS and chloramines-T in MeCN at reflux, hydrogenolysis of azridinyl ketone, Grignard methylation of amino ketone, BF3·OEt2-promoted cyclization of amino alcohol, and desulfonylation with Mg and Et3N in MeOH. Anthracene skeleton 9 is also synthesized via an intramolecular rearrangement of pinacol to pinacolone.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
