One-pot, three-component synthesis of highly functionalized 1,3-oxazine derivatives from α,β-unsaturated imine, alkyne, and aldehyde

The 1,4-dipoles generated from imines and DMAD have been shown to react efficiently with benzylaldehyde dipolarphiles in one-pot [4+2] annulation resulting in the diversity oriented synthesis of 1,3-oxazine derivatives in good to excellent yields.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide