| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219822 | Tetrahedron | 2012 | 9 Pages |
Abstract
The bromination of activated 4,6-dimethoxyindoles can be carried out effectively provided that an electron-withdrawing group is also present. Thus the range of products includes 2-bromo-7-formyl or 2-bromo-7-acetylindoles 13a-c and 16, 7-bromo-2-acetylindole 21, 2,5-dibromo-7-acetylindole 17, 2,5-dibromo-N-sulfonylindole 27, and 2,7-dibromo-N-acetylindole 24. Acetyl and sulfonyl protecting groups on nitrogen can be removed to give 2-bromoindoles 28a-b, 2,5-dibromoindole 29, and 2,7-dibromoindole 4.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peter S.R. Mitchell, Ibrahim F. Sengul, Hakan Kandemir, Stephen J. Nugent, Rui Chen, Paul K. Bowyer, Naresh Kumar, David StC. Black,