| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5219903 | Tetrahedron | 2012 | 9 Pages |
Abstract
A study on transition metal catalyzed alkyne cyclotrimerization of unsymmetrically bromo-substituted diynes with ethynyltrimethylsilane was carried out to prepare bicyclic bromobenzene key intermediates for the total synthesis of five potential tyrosine kinase 2 inhibitors. Two different pre-catalysts (Cp*RuCl(cod) and [Rh(cod)2]BF4/BINAP) and different reaction conditions have been examined.
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