Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219960 | Tetrahedron | 2011 | 8 Pages |
Abstract
The combination of [Cp*IrCl2]2 with N-(2-aminoethyl)-4-(trifluoromethyl)benzenesulfonamide constitutes an efficient catalyst for selective transfer hydrogenation of a variety of quinoxalines in water with HCOONa as the hydrogen source, affording the corresponding tetrahydroquinoxalines in good to excellent yields. The catalyst is air-stable, and the reduction could be performed without nitrogen protection. The aqueous phase reduction is shown to be highly pH-dependent, with acidic pH leading to better results. There exits a pH window for optimum rate, and the use of HOAc/NaOAc buffer solution is essential for maintaining a stable pH during the reaction.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jing Tan, Weijun Tang, Yawei Sun, Zhen Jiang, Fei Chen, Lijin Xu, Qinghua Fan, Jianliang Xiao,