Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219970 | Tetrahedron | 2011 | 8 Pages |
Abstract
An enantioselective approach to the C28 fatty acid chain of the marine natural products schulzeines B and C was established based on the l-tartaric acid derived C4 chiron 11 via successive 1,4-bis-chain elongation reactions and catalytic asymmetric hydrogenation. The chiral tricyclic core 8 was constructed via a diastereoselective Pictet-Spengler cyclization reaction (dr = 89:11) of the l-glutamic acid derived precursor 13. On this basis, a concise total synthesis of (â)-schulzeine B (5) was disclosed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chao Yang, Yu-Hui Bao, Pan Liang, Jian-Liang Ye, Ai-E. Wang, Pei-Qiang Huang,