Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5219998 | Tetrahedron | 2012 | 7 Pages |
Abstract
A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)2O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected secondary amines even in those cases where the products are prone to intramolecular lactamization.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raghupathi Neelarapu, Pavel A. Petukhov,