Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220009 | Tetrahedron | 2012 | 8 Pages |
Abstract
A flexible route for the stereoselective synthesis of a variety of 3-aryl dihydroisoquinolones and tetrahydroisoquinolines has been developed. The key step is a diastereoselective photoinduced 6Ï-electrocyclic ring closure of enantiopure aromatic enehydrazides via a 1,4-remote asymmetric induction. N-N bond cleavage to release the chiral appendage from the preliminary annulated compounds and/or concomitant reduction of the lactam carbonyl group completed the synthesis of the title compounds.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mélanie Dubois, Eric Deniau, Axel Couture, Pierre Grandclaudon,