| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220036 | Tetrahedron | 2011 | 5 Pages |
Abstract
A direct method to construct 3,4-dihydropyridin-2-ones by enzymatic condensation of aldehyde with cyanoacetamide and 1,3-dicarbonyl compounds was developed. One ring and four new bonds (two C-C, one C-N, one CC) were formed in one pot. And reaction conditions involving hydrolases, solvents, substrate molar ratios, and hydrolase loading were optimized. A series of new compounds based on the 3,4-dihydropyridin-2-one core were synthesized by the unprecedented three-component domino reaction.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhi-Qiang Liu, Bo-Kai Liu, Qi Wu, Xian-Fu Lin,