| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220044 | Tetrahedron | 2012 | 5 Pages |
Abstract
Two new cytotoxic oxasqualenoids, saiyacenols A and B, were isolated from the red alga Laurencia viridis and their structures elucidated by spectroscopic methods and chemical correlation with the well-known compound dehydrothyrsiferol. The new compounds share an important part of their structure with thyrsiferol and aplysiols B and C. Isolation of the saiyacenols concludes the controversy about the configuration of aplysiols, correcting the structure of aplysiol B. Our results illustrate the current limitations of NMR J-based methods when approaching quaternary carbons and demand a reappraisal of rational biogenetic proposals in structural elucidation.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Francisco Cen-Pacheco, Faustino Mollinedo, Janny A. Villa-PulgarÃn, Manuel Norte, José J. Fernández, Antonio Hernández Daranas,