Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220068 | Tetrahedron | 2012 | 7 Pages |
Abstract
Herein we evaluate different methodologies for the synthesis of unprotected sulfonimidamides. Three different procedures that allow orthogonal deprotection of the imine nitrogen under acidic, nucleophilic, and basic conditions were established. Moreover, we present a highly efficient methodology for functionalization of the imine nitrogen through Pd-catalyzed C-N arylation. RuPhos ligand was shown to allow short reaction time, excellent yields, and allowed coupling of both aryl halides and heteroaryl bromides.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
MatÃas Funes Maldonado, Fernando Sehgelmeble, Fanny Bjarnemark, Mats Svensson, Jens Ã
hman, Per I. Arvidsson,