| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220112 | Tetrahedron | 2011 | 6 Pages |
Abstract
Various N,N-dimethyl amides, N-methoxy-N-methyl amides, and isopropyl esters were smoothly transformed into the corresponding nitriles in good to moderate yields by the treatment with diisobutylaluminium hydride, followed by treatment with molecular iodine in aq ammonia. The present reactions are novel one-pot and practical methods for the transformation of N,N-disubstituted amides and isopropyl esters into nitriles, through the formation of hemiaminal O-AlBu2 and hemiacetal O-AlBu2, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yusuke Suzuki, Takumi Yoshino, Katsuhiko Moriyama, Hideo Togo,