| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220116 | Tetrahedron | 2011 | 7 Pages |
Abstract
A convenient method for the synthesis of bicyclic 4-aminopyrimidines is described, involving the reaction of dinitriles with mononitriles in the presence of catalytic potassium tert-butoxide. These reactions proceed via the Thorpe–Ziegler cyclization of the dinitrile to form an intermediate β-cyanoenamine, which then undergoes annulation with the mononitrile in situ.
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